WADDP Research: Open for Innovation Our research is translational and focused on advancing Drug Delivery Technology, Nanomedicine, Tissue Engineering, Regenerative Medicine, 3D-Bioprinting and Bio-Inspired Systems of the future.
WADDP Research: Open for Innovation Our research is translational and focused on advancing Drug Delivery Technology, Nanomedicine, Tissue Engineering, Regenerative Medicine, 3D-Bioprinting and Bio-Inspired Systems of the future.
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We innovate at the interface of pharmaceutical, biotechnology, nanotechnology and biomaterials science. New drugs (and other bioactive molecules) have attractive properties and are continually been developed. Regrettably, some have very short in vivo half-lives or poor solubility and physicochemical stability resulting in a low bioavailability and ultimately limits the drugs clinical use because of either erratic plasma drug concentrations or poor patient compliance (side-effects and dosing convenience).

These challenges can be circumvented by our research that employs futuristic techniques. We merge the concept of in silico methods to design systems that can be pre-programmed using a suite of computing algorithms (DoE, ANN, Molecular Static and Dynamic Simulations, Pharmacokinetic Modeling Analysis, Image Processing Analysis, QbD) to create, optimize and simulate advanced drug delivery modules. Our MRI imaging technology for mapping the fluid dynamics within drug delivery systems is unique worldwide. 

We work collaboratively with researchers spanning across diverse disciplines, including biologists, chemists, physicists, chemical engineers, immunologists, neurosurgeons, neurologists, ophthalmologists, obstetricians, gynaecological oncologists as well as a host of other specialist clinicians who bring complementary expertise to optimize health and wellness and solve the most unrelenting diagnostic and therapeutic challenges facing patient populations.

As the pathophysiology of disease becomes clearer, the requirement for targeted and personalized therapies to improve the quality of life of patients has surged, and our research plays an integral role. Our team is highly regarded for many breakthrough technologies emanating from our labs. A selection of these advances are outlined below:

  • Repair and regeneration of the injured spinal cord using 3D neuro-injectable scaffolds/hydrogels
  • Targeted therapies in ovarian and cervical cancer using antibody-functionalized nanosystems
  • Ocular devices for anterior/posterior segment disease using ocular-terials, geo-solid drops
  • Nano-co-Plexes for magnetic intranasal delivery of carmustine for targeted treatment of glioma
  • 3D-BioPrinted geo-scaffolds for spatial control of cell differentiation using self-assembled bioinks
  • First in-the-world chelating nanosystems as intracranial implants for neurodegenerative diseases
  • Intra-arterial sensory devices to monitor and treat high blood factors in chronic lifestyle diseases
  • Stimuli-responsive oral ghost matrices and core-melt tablets to deliver proteins/peptides orally
  • Pioneered PEiGOR to describe jump diffusion in electro-active hydrogels for neuropathic pain
  • First-in-the-world stimuli-active matrices for spaced-defined drug release in ulcerative colitis
  • The first-ever MRI analysis of hydration dynamics in oral layered tablets using in silico modeling
  • Intravaginal devices to reduce and prevent STI/HIV transmission using VagiTab technology
  • In situ forming nanogels with neuroblasts or mature neurons for treating neurodegeneration
  • Functionalized carbon nanotubes for targeted treatment of stroke using novel aptamer technology
  • Nano-reinforced cryogel scaffolds for neural tissue regeneration using 3D-Bioprinted models
  • Neuro-replacement therapy in traumatic brain injury using a 3D-BioPrinted neuro-mimicry system
  • Arresting CS-proteoglycans progression in ovarian cancer using X-linked extracellular nanosystem
  • Thixotropic synovial bio-fluid for orthopaedic insertion using polysaccharide infused glucosamine
  • 3D-BioPrinted biofilms for burn and diabetic foot wound healing as a bio-inspired pseudo-skin
  • Synthesis of redox-active drugs to treat TB and malaria based on clofazimine redox chemistry

 While we pursue diverse projects, they are linked to the following Thematic Areas:

  • Ultra-Fast Oral Dissolving Matrices
  • Nano-NeuroPharmaceutical Devices
  • Interventions for Neural Tissue Regeneration
  • Targeted Cancer Therapies
  • Biodegradable Ocular Inserts for Bioactive Delivery
  • Oral Delivery of Proteins and Peptides
  • Targeted Anti-Thrombolytic Systems
  • Advanced Wound Healing Platforms
  • Chronotherapeutic Technologies
  • Gastroretentive Systems for NAW Molecules
  • Theranostic Systems 
  • 3D-BioPrinting of Biomimetic Scaffolds
  • Nanomedicine and Nanovector Technologies
  • Stimuli-Responsive Biomaterials
  • Probiotics and Nutraceuticals
  • PharMATHaceutics for System Optimization  
  • Pharmaceutical Reformulation

     

 
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