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Research Outputs

Research Outputs

 

Publications

 

The WADDP has over 200 research publications in top-ranking internationally ISI-recognized peer-reviewed scientific journals. Below is a representative list of original research articles and critical review papers published since 2012. (Access to publications prior to 2012 is available on request).

 

  1. A symbiotic glance at the complexities of signature microbiomic interventions: Infusing balance, Pradeep Kumar, Yahya E. Choonara, Viness Pillay, South African Journal of Science, 110(11/12), 12-16, 2014.
  2. A review of advanced oral drug delivery technologies facilitating the protection and absorption of protein and peptide molecules, Bibi F. Choonara, Yahya E. Choonara, Pradeep Kumar, Divya Bijukumar, Lisa C. du Toit and Viness Pillay, Biotechnology Advances, 32(7), 1269-1282, 2014.
  3. An epichlorohydrin-crosslinked semi-interpenetrating GG-PEO network as a xerogel matrix for sustained release of sulpiride, Famida G.Hoosain, Yahya E. Choonara, Pradeep Kumar, Lomas K. Tomar, Charu Tyagi, Lisa C. du Toit and Viness Pillay, AAPS PharmSciTech, 15(5), , 1292-1306, 2014.
  4. A comprehensive review of advanced biopolymeric wound healing systems, Naeema Mayet, Yahya E. Choonara, Pradeep Kumar, Lomas K. Tomar, Charu Tyagi, Lisa C. du Toit and Viness Pillay, Journal of Pharmaceutical Sciences, 103(8), 2211–2230, 2014.
  5. Development and validation of dot-ELISA on modified cellulose filter paper: a simplified novel approach, Charu Tyagi, Lomas K. Tomar, Pradeep Kumar, Viness Pillay and Harpal Singh, Analytical Methods, 6, 7374-7383, 2014.
  6. A review of bioactive release from nerve conduits as a neurotherapeutic strategy for neuronal growth in peripheral nerve injury, Poornima Ramburrun, Pradeep Kumar, Yahya E. Choonara, Divya Bijukumar, Lisa du Toit and Viness Pillay, BioMed Research International, Volume 2014 (2014), Article ID 132350, 1-19, 2014.
  7. A review of integrating electroactive polymers as responsive systems for specialized drug delivery applications, Viness Pillay, Tong-Sheng Tsai, Yahya E. Choonara, Lisa C. du Toit, Girish Modi, Dinesh Naidoo, Lomas K. Tomar, Charu Tyagi, Pradeep Kumar and Valence M.K. Ndesendo, Journal of Biomedical Materials Research- Part A, 102(6), 2039–2054, 2014.
  8. Current Advances in the Fabrication of Microneedles for Transdermal Delivery, Sunaina Indermun, Regina Luttge, Yahya E. Choonara, Pradeep Kumar, Lisa C. du Toit, Girish Modi and Viness Pillay, Journal of Controlled Release, 185 130-138, 2014.  
  9. In vivo evaluation and of a rapidly dissolving solid ocular matrix for the topical delivery of timolol maleate in the rabbit eye model, Raeesa Moosa, Yahya E. Choonara, Lisa C. du Toit, Lomas K. Tomar, Charu Tyagi, Pradeep Kumar, Trevor R. Carmichael and Viness Pillay, International Journal of Pharmaceutics, 466(1-2), 296-306, 2014.
  10. In vivo and ex vivo evaluation of a multi-particulate composite construct for sustained transbuccal delivery of carbamazepine, Oluwatoyin A. Adeleke, Yahya E. Choonara, Lisa C. du Toit and Viness Pillay, Journal of Pharmaceutical Sciences, 103(4), 1157-1169, 2014.
  11. Patient-controlled analgesia: Therapeutic interventions using transdermal electro-activated and modulated (TEAM) drug delivery, Sunaina Indermun, Yahya E. Choonara, Pradeep Kumar, Lisa C. du Toit, Girish Modi, Regina Luttge and Viness Pillay, Journal of Pharmaceutical Sciences, 103(2), 353-366, 2014.
  12. In vitro, in vivo, and in silico evaluation of the bioresponsive behavior of an intelligent intraocular implant, Lisa C. du Toit, Trevor Carmichael, Thirumala Govender, Pradeep Kumar, Yahya E. Choonara and Viness Pillay, Pharmaceutical Research, 31(3), 607-634, 2014.
  13. Review of topically administered mini-tablets for drug delivery to the anterior segment of the eye, Raeesa Moosa, Yahya E. Choonara, Lisa C. du Toit, Pradeep Kumar, Trevor Carmichael, Lomas Kumar Tomar, Charu Tyagi and Viness Pillay, Journal of Pharmacy and Pharmacology, 66(4), 490-506, 2014.
  14. Cur(Que)min: A neuroactive permutation of curcumin and quercetin for treating spinal cord injury, Pradeep Kumar, Yahya E. Choonara, Girish Modi, Dinesh Naidoo and Viness Pillay, Medical Hypothesis, 82:437-441, 2014.
  15. In silico elucidation of the inclusion phenomenon and permeation behavior of a zidovudine-cyclodextrin complex via static lattice atomistic simulation, Pradeep Kumar, Yahya E. Choonara, Lisa C. du Toit, and Viness Pillay, Journal of Inclusion Phenomena and Macrocyclic Chemistry, 78:445-455, 2014.
  16. Electrospun nanofiber matrix with a mucoadhesive backing film for oramucosal drug delivery, Charu Tyagi, Lomas K. Tomar, Yahya E. Choonara, Lisa C. du Toit, Pradeep Kumar and Viness Pillay, International Journal of Materials, Mechanics and Manufacturing, 2(1), 81-85, 2014.
  17. Nutraceutical-based therapeutics and formulation strategies augmenting their efficiency to complement modern medicine: An overview, Miles C. Braithwaite, Charu Tyagi, Lomas K. Tomar, Pradeep Kumar, Yahya E. Choonara, Journal of Functional Foods, 6:82-99, 2014.
  18. An Overview of the Role of Nano-Technological Innovations in the Detection and Treatment of Solid Tumors, Derusha Frank, Charu Tyagi, Lomas Tomar, Yahya E. Choonara, Lisa C. du Toit,  Pradeep Kumar, Clement Penny and Viness Pillay, International Journal of Nanomedicine, 9(1), 589-613, 2014.
  19. Nanoparticulate strategies for the 5 R’s of traumatic spinal cord injury intervention: Restriction, repair, regeneration, restoration and reorganization, Pradeep Kumar, Yahya E. Choonara, Girish Modi, Dinesh Naidoo, and Viness Pillay, Nanomedicine, 9(2), 331-348, 2014.
  20. An interfacially plasticized electro-responsive hydrogel for transdermal electro-activated and modulated (TEAM) drug delivery, Sunaina Indermun, Yahya E. Choonara, Pradeep Kumar, Lisa C. du Toit, Girish Modi, Regina Luttge and Viness Pillay,  International Journal of Pharmaceutics, 462(1-2), 52-65, 2014. 
  21. A review of the advancements in probiotic delivery: Conventional vs. non-conventional formulations for intestinal flora supplementation, Mershen Govender, Yahya E. Choonara, Pradeep Kumar, Lisa C. du Toit, Sandy van Vuuren and Viness Pillay, AAPS PharmSciTech, 15(1), 29-43, 2014.
  22. Evaluation of the impact of formulation variables and excipients on the drug release dynamics of a polyamide 6,10-based monolithic matrix using mathematical tools, Oluwatoyin A. Adeleke, Yahya E. Choonara, Pradeep Kumar, Lisa C. du Toit, Lomas K. Tomar, Charu Tyagi and Viness Pillay, AAPSPharmSciTech, 14(4), 1349-1359, 2013.
  23. Prolonged Delivery of Ciprofloxacin and Diclofenac Sodium from a Polymeric Fibre Device for the Treatment of Peridontal Disease, Deanne Johnston, Yahya E. Choonara, Pradeep Kumar, Lisa du Toit, Sandy van Vuuren and Viness Pillay, Biomedical Research International, Article ID 460936, 2013.
  24. Oral Bioavailability and Neuro-Availability vs. “Neuro-Transmittability”: A Figment of Imagination in the Conundrum of Neuronal Intervention, Viness Pillay, Pradeep Kumar and Yahya E Choonara, Journal of Bioequivalence and Bioavailability, 5(5), 1-2, 2013.
  25. A Mucoadhesive Electrospun Nanofibrous Matrix for Rapid Oramucosal Drug Delivery, Clare Dott, Charu Tyagi, Lomas Tomar, Yahya E. Choonara, Pradeep Kumar, Lisa du Toit and Viness Pillay, Journal of Nanomaterials, Article ID 924947, 2013.
  26. Exploration of the Biomacromolecular Interactions of an Interpenetrating Proteo-Saccharide Hydrogel Network at the Mucosal Interface, Felix Mashingaidze, Yahya E. Choonara Pradeep Kumar, Lisa C. du Toit, Vinesh Maharaj, Eckhart Buchmann, Valence M.K. Ndesendo and Viness Pillay, Journal of Biomedical Materials Research- Part A, 101A, 3616–3629, 2013. 
  27. A Hybrid Methacrylate-Sodium Carboxymethylcellulose Interpolyelectrolyte Complex: Rheometry and In Silico Disposition for Controlled Drug Release, Ndidi Ngwuluka, Yahya E. Choonara, Pradeep Kumar, Girish Modi, Lisa C. du Toit, Viness Pillay, Materials, 6(10), 4284-4308, 2013. 
  28. A Novel pH-Sensitive Interferon-β (INF-β) Oral Delivery System for Application in Multiple Sclerosis, Pierre P.D. Kondiah, Lomas K. Tomar, Charu Tyagi, Yahya E. Choonara, Girish Modi, Lisa C. du Toit, Pradeep Kumar and Viness Pillay, International Journal of Pharmaceutics, 456(2):459-72, 2013.
  29. Monolayered multipolymeric buccal films with drug and polymers of opposing solubilities for ARV therapy: Physico-mechanical evaluation and molecular mechanics modeling, Elsabé Jones, Elizabeth Ojewole, Viness Pillay, Pradeep Kumar, Sanjeev Rambharose, Thirumala Govender, International Journal of Pharmaceutics, 455(1-2):197-212, 2013.
  30. Vitamin D Therapy and Related Metabolomics: Is the Calciferol Dose and Form the Only Requirements for Successful Clinical Therapeutics?, Miles C. Braithwaite, Pradeep Kumar, Charu Tyagi, Lomas K. Tomar, Yahya E. Choonara and Viness Pillay, 81(4), 656-663, 2013.
  31. Physicomechanical Characterization and Optimization of EDTA-mPEG and Avicel®-EDTA-mPEG In Situ Melt Dispersion Mini-Pellets, Angus R. Hibbins, Yahya E. Choonara, Pradeep Kumar, Lisa C. du Toit and Viness Pillay, AAPSPharmSciTech, 14(3), 935-949, 2013.
  32. A Novel Multi-Layered Multi-Disk Oral Tablet for Chronotherapeutic Drug Delivery, Zaheeda Khan, Yahya E. Choonara, Pradeep Kumar, Lisa du Toit, Valence Ndesendo and Viness Pillay, Biomedical Research International, Volume 2013, Article ID 569470, 1-16, 2013.
  33. Design of an Anti-Inflammatory Composite Nanosystem and Evaluation of its Potential for Ocular Drug Delivery, Lisa C. du Toit, Thirumala Govender, Trevor Carmichael, Pradeep Kumar, Yahya E. Choonara and Viness Pillay, Journal of Pharmaceutical Sciences, 102(8):2780-2805, 2013.
  34. Design and Pharmaceutical Evaluation of an Implantable Nano-Enabled Crosslinked Multipolymeric Scaffold for Prolonged Intracranial Release of Zidovudine, Sheri-lee Harilall, Yahya E. Choonara, Girish Modi, Lomas K. Tomar, Charu Tyagi, Pradeep Kumar, Lisa C. du Toit, Sunny E. Iyuke, Michael P. Danckwerts and Viness Pillay, Journal of Pharmacy & Pharmaceutical Sciences, 16(3) 470 - 485, 2013.
  35. Five Decades of Sci-Fi in Drug Delivery, Viness Pillay, Pradeep Kumar, Lisa C. du Toit and Yahya E. Choonara, Therapeutic Delivery 4(3), 285-287, 2013.
  36. A Prospective Overview of the Essential Requirements in Molecular Modeling for Nanomedicine Design, Viness Pillay, Pradeep Kumar, Yahya E. Choonara and Riaz A. Khan, Future Medicinal Chemistry, 5(8), 929-946, 2013.
  37. Integration of Biosensors and Drug Delivery Technologies for Early Detection and Chronic Management of Illness, Mpho Ngoepe, Yahya E. Choonara, Charu Tyagi, Lomas K. Tomar, Lisa C. du Toit, Pradeep Kumar, Valence Ndesendo and Viness Pillay, Sensors, 13(6), 7680-7713, 2013.
  38. Modulation of the Nano-Tensile Mechanical Properties of Co-Blended Amphiphilic Alginate Fibers as Oradurable Biomaterials for Specialized Biomedical Application, Deanne Johnston, Pradeep Kumar, Yahya E. Choonara, Lisa C. du Toit and Viness Pillay, Journal of the Mechanical Behavior of Biomedical Materials, 23, 80-102, 2013.
  39. A Review of Polymeric Refabrication Techniques to Modify Polymer Properties for Biomedical and Drug Delivery Applications, Viness Pillay, Ahmed Seedat, Yahya E. Choonara, Lisa C. du Toit, Pradeep Kumar and Valence M. K. Ndesendo, AAPSPharmSci Tech, 14(2), 692-711, 2013.
  40. Design of an Interpolyelectrolyte Gastroretentive Matrix for the Site-Specific Zero-Order Delivery of Levodopa in Parkinson’s Disease, Ndidi C. Ngwuluka, Yahya E. Choonara, Girish Modi, Lisa C. du Toit, Pradeep Kumar, Valence M.K. Ndesendo and Viness Pillay, AAPSPharmSci Tech, 14(2), 605-619, 2013.
  41. A Novel pH-Dependant and Double Crosslinked Polymethacrylate-Based Polysphere Matrix for Enteric Delivery of Isoniazid, Shivaan Cooppan, Viness Pillay, Yahya E. Choonara, Lisa C. du Toit, Valence M.K. Ndesendo and Pradeep Kumar, Pharmaceutical Development and Technology, 18(5), 1066-1077, 2013.
  42. In silico analytico-mathematical interpretation of biomacro-molecular assemblies for biomedical applications: Quantification of energy surfaces and molecular attributes using atomistic simulations, Pradeep Kumar, Yahya E. Choonara, Lisa C. du Toit and Viness Pillay, Journal of Material Science and Engineering, 2:4, 212-212, 2013.
  43. Micromechanical and physical stability analysis of an irradiated poly(lactic-co-glycolic acid) donut-shaped minitablet device for intraocular implantation, Yahya E. Choonara, Viness Pillay, Michael P. Danckwerts, Trevor R. Carmichael, Lisa C. du Toit and Riaz A. Khan, Pharmaceutical Development and Technology, 18(5), 1186-1203, 2013.
  44. Ligand-Functionalized Nanoliposomes for Targeted Delivery of Galantamine,  Maluta S. Mufamadi, Yahya E. Choonara, Pradeep Kumar, Girish Modi, Dinesh Naidoo, Sandy van Vuuren, Valence M.K. Ndesendo, Lisa C. du Toit, Sunny E. Iyuke and Viness Pillay, International Journal of Pharmaceutics, 448(1), 267-81, 2013.
  45. A Novel Gastric Release PEG-Enclatherated Polymethacrylate-Based Memblet System, Shivaan Cooppan, Yahya E. Choonara, Lisa C. du Toit, Pradeep Kumar, Valence Ndesendo and Viness Pillay, Journal of Applied Polymer Science, 128, 4327-4338, 2013.
  46. In vivo evaluation of a conjugated poly(lactide-ethylene glycol) nanoparticle depot formulation for prolonged insulin delivery in the diabetic rabbit model, Lomas Tomar, Charu Tyagi, Manoj Kumar, Pradeep Kumar, Harpal Singh, Yahya E. Choonara and Viness Pillay, International Journal of Nanomedicine, 8, 505-520, 2013.
  47. A Review of the Effect of Processing Variables on the Fabrication of Electrospun Nanofibers for Drug Delivery Applications, Viness Pillay, Clare Dott, Yahya E. Choonara, Charu Tyagi, Lomas Tomar, Pradeep Kumar, Lisa C. du Toit and Valence M. K. Ndesendo, Journal of Nanomaterials, Article ID 789289, 2013. 
  48. A Novel Stimuli-Synchronized Alloy-Treated Matrix for Space-Defined Gastrointestinal Delivery of Mesalamine in the Large White Pig Model, Priya Bawa, Yahya E. Choonara, Lisa C. du Toit, Pradeep Kumar, Valence M.K. Ndesendo, Leith C.R. Meyer and Viness Pillay, Journal of Controlled Release, 166(3), 234-245, 2013
  49. Flavonoids and Polymer-Derivatives as CYP3A4 Inhibitors for Improved Oral Drug Bioavailability: An In Vitro and In Silico Comparative Analysis, Pius Fasinu, Yahya E. Choonara, Riaz A. Khan, Lisa C. du Toit, Pradeep Kumar, Valence M.K. Ndesendo and Viness Pillay, Journal of Pharmaceutical Sciences, 102(2):541-555, 2013.
  50. Novel High-Viscosity Polyacrylamidated Chitosan for Neural Tissue Engineering: Fabrication of Anisotropic Neurodurable Scaffold via Molecular Disposition of Persulfate-Mediated Polymer Slicing and Complexation, Pradeep Kumar, Yahya E. Choonara, Lisa C. Du Toit, Girish Modi, Dinesh Naidoo and Viness Pillay, International Journal of Molecular Sciences, 13, 13966-13984, 2012.
  51. Orally Administered Therapeutic Peptide Delivery: Enhanced Absorption through the Small Intestine using Permeation Enhancers, Viness Pillay, Angus Hibbins, Yahya E. Choonara, Lisa C. du Toit, Pradeep Kumar and Valence M.K. Ndesendo, International Journal of Peptide Research and Therapeutics, 18(3), 259-280, 2012.
  52. Composite Polylactic-Methacrylic Acid Copolymer Nanoparticles for the Delivery of Methotrexate, Bongani Sibeko, Yahya E. Choonara, Lisa C. du Toit, Girish Modi, Dinesh Naidoo, Riaz Khan, Valence Ndesendo, Pradeep Kumar, Sunny Iyuke and Viness Pillay, Journal of Drug Delivery, Article ID 579629, 2012.
  53. Surface-Engineered Nanoliposomes by Chelating Ligands for Modulating the Neurotoxicity Associated with β-Amyloid Aggregates of Alzheimer's disease, Steven Mufamadi, Yahya E. Choonara, Pradeep Kumar, Girish Modi, Dinesh Naidoo, Valence Ndesendo, Lisa C. du Toit, Leith C.R. Meyer, Sunny E. Iyuke and Viness Pillay, Pharmaceutical Research, 29, 3075–3089, 2012.  
  54. In vitro evaluation of the physicochemical effects of drug-loaded carbon nanotubes on toxicity, Nyaradzo Chigumbu, Sunny Iyuke, Viness Pillay and Sehliselo Ndlovu, Journal of Nanomedicine and Nanotechnology, 3(4), 1-7, 2012. 
  55. Optimization of a polymer composite employing molecular mechanic simulations and artificial neural networks for a novel intravaginal bioadhesive drug delivery device, Valence M.K. Ndesendo, Viness Pillay, Yahya E. Choonara, Lisa C. du Toit, Pradeep Kumar, Eckhart Buchmann, Leith C.R. Meyer and Riaz A. Khan, Pharmaceutical Development and Technology, 17(4), 407-420, 2012.
  56. Advanced preformulation investigations for the development of a lead intravaginal bioadhesive polymeric device, Valence M.K. Ndesendo, Viness Pillay, Yahya E. Choonara, Lisa C. du Toit, Eckhart Buchmann, Pradeep Kumar, Riaz A. Khan and Leith C.R. Meyer, Drug Development and Industrial Pharmacy, 38(3):271-93, 2012.
  57. Crosslinked electrospun PVA nanofibrous membranes: Elucidation of their physicochemical, physicomechanical and molecular disposition, Rubina Shaikh, Pradeep Kumar, Yahya E. Choonara, Lisa C. du Toit and Viness Pillay, Biofabrication, 4(2), 025002, 2012.
  58. Qualitative and Quantitative Intravaginal Targeting: Key to anti-HIV-1 Microbicide Delivery from Test-Tube to In Vivo Success, Viness Pillay, Felix Mashingaidze, Yahya E. Choonara, Lisa C. du Toit, Eckhart Buchmann, Vinesh Maharaj, Valence Ndesendo and Pradeep Kumar, Journal of Pharmaceutical Sciences, 101:1950–1968, 2012.
  59. Optimization of a dual mechanism gastrofloatable and gastroadhesive delivery system for narrow absorption window drugs, Caragh S. Murphy,  Viness Pillay, Yahya E. Choonara, Lisa C. du Toit, Valence M.K. Ndesendo, Nthato Chirwa and Pradeep Kumar, AAPS PharmSciTech, 13(1):1-15, 2012.
  60. The application of a crosslinked pectin-based wafer system for gradual buccal drug delivery, Rubina P. Shaikh, Viness Pillay, Yahya E. Choonara, Lisa C. du Toit, Valence M.K. Ndesendo, Pradeep Kumar and Riaz A. Khan, Journal of Biomedical Materials Research Part B: Applied Biomaterials, 100(4):1029-43, 2012.
  61. Oral drug delivery systems comprising altered geometric configurations for controlled drug delivery, Kovanya Moodley, Viness Pillay, Yahya E. Choonara, Lisa C. du Toit, Valence M.K. Ndesendo, Pradeep Kumar, Shivaan Cooppan and Priya Bawa, International Journal of Molecular Sciences, 13, 18-43, 2012.
  62. Polyphenol-flavonol synergistic paradigm for neural repair: Combinatorial computational modeling approach for post-traumatic m-calpain inactivation, Pradeep Kumar, Viness Pillay, Yahya E. Choonara, Lisa C. du Toit, Girish Modi and Dinesh Naidoo, Neurorehabilitation and Neural Repair; 26(6), NP1–NP13, 2012.
  63. A combinatorial in silico approach to model the glycosylated, nornicotine-curcumin paradigm in neuroprotection and neurotherapy for Alzheimer’s disease, Pradeep Kumar, Viness Pillay, Yahya E. Choonara, Lisa C. du Toit, Girish Modi and Dinesh Naidoo, International Journal of Developmental Neuroscience, 30(8), 674-675, 2012.
  64. Exploration of a composite nano-medical device for the delivery of neuroprotectant-nanocarriers into targeted neuronal cells of Alzheimer's disease, Steven Mufamadi, Yahya E. Choonara, Lisa C. du Toit, Girish Modi, Dinesh Naidoo, Pradeep Kumar, Valence M.K. Ndesendo, Leith C.R. Meyer, Sunny E. Iyuke and Viness Pillay, European Journal of Neurology, 19(S1), 94-94, 2012.
  65. Physicomechanical transitions of an implantable nano-enabled biorobotic intracranial device for Alzheimer's disease management for validation of in vivo behaviour in a simulated brain environment, Steven Mufamadi, Yahya E. Choonara, Lisa C. du Toit, Girish Modi, Dinesh Naidoo, Pradeep Kumar, Valence M.K. Ndesendo, Leith C.R. Meyer, Sunny E. Iyuke and Viness Pillay, European Journal of Neurology, 19(S1), 102-102, 2012.
  66. Design, biomolecular modelling and evaluation of surface-engineered nanoliposomes for the management of Alzheimer's disease, Steven Mufamadi, Yahya E. Choonara, Lisa C. du Toit, Girish Modi, Dinesh Naidoo, Pradeep Kumar, Valence M.K. Ndesendo, Leith C.R. Meyer, Sunny E. Iyuke and Viness Pillay, European Journal of Neurology, 19(S1), 445-445, 2012.
  67. Poly (PEGDMA-MAA) copolymeric micro and nanoparticles for oral insulin delivery: A molecular mechanistic revisit, Lomas Tomar, Charu Tyagi, Pradeep Kumar, Yahya E. Choonara, Lisa du Toit and Viness Pillay, International Journal of Pharmacology and Pharmaceutical Technology, 1(2), 2277-3436, 2012.
  68. pH-Responsive polymeric nanoparticles for oral insulin delivery, Charu Tyagi, Lomas Tomar, Pradeep Kumar, Yahya E. Choonara, Lisa C. du Toit, Harpal Singh and Viness Pillay, International Journal of Pharmacology and Pharmaceutical Technology, 1(2), 6-10, 2012.

 

Book Chapters

 

  1. Nose-to-Brain Neurotherapeutic Interventions. In: Advances in Neurotherapeutic Delivery Technologies, Viness Pillay, Olufemi D. Akilo, Yahya E. Choonara, Pradeep Kumar, Lisa C. du Toit. Edited by Viness Pillay and Yahya E. Choonara, OMICS Publishing Group, In press, 2015.
  2. Customized shape memory biopolymers, Viness Pillay, Lisa C. du Toit, Thashree Marimuthu, Pradeep Kumar and Yahya E. Choonara. In: Unfolding the Biopolymer Landscape. Edited by Viness Pillay and Yahya E. Choonara, Bentham Science Publishers, In press, 2015.
  3. Prolamine-based matrices for biomedical applications, Viness Pillay, Pradeep Kumar and Yahya E. Choonara, In: Handbook of Polymers for Pharmaceutical Technologies edited by Vijay Kumar Thakur, Wiley Scrivener, In press, 2015.
  4. Injectable Thermogels for Biomedical Applications, In: Intelligent drug delivery systems, Viness Pillay, Pradeep Kumar and Yahya E. Choonara. Edited by MM Amiji and A Singh, Future Science Group, In press, 2015.
  5. Formulation Approaches for the Oral Delivery of Vaccines: Concepts and Prospects, Viness Pillay, Pradeep Kumar, Yahya E. Choonara. In: Advances and challenges in oral delivery of macromolecules. Edited by Greg Russell-Jones. Future Science Group. Accepted for publication. In Press, 2014.
  6. Nano(neuro)medicinal Interventions for Neurodegenerative Disorders: Concurrent Challenges and Strategic Solutions, Viness Pillay, Pradeep Kumar, Girish Modi, Yahya E. Choonara. In: Recent Advances in Novel Drug Carrier Systems. Editor: Ali Demir Sezer. Science Publishers and CRC Press. Accepted for publication. In Press.
  7. Dosage Forms for Microbicides Formulation: Advantages and Pitfalls, Viness Pillay, Pradeep Kumar, Valence M.K. Ndesendo, Yahya E. Choonara, Lisa C. du Toit. In: Drug Delivery and Development of Anti-HIV Microbicides. Editor: José das Neves and Bruno Sarmento. Pan Stanford Publishing Pte. Ltd. Accepted for publication. Pan Stanford 2014. Pages 193–219. DOI: 10.1201/b17559-7
  8. Cutting-Edge Techniques for Molecular Imaging with Relevance to Therapeutic Delivery Methods, Future Science Group, Viness Pillay, Pradeep Kumar and Yahya E. Choonara, In: Therapeutic delivery methods: concise overview of emerging areas (eBook), Editor: Professor Beom-Jin Lee, Future Science Group, Pages 126-144, doi:10.4155/ebo.13.253, 2013.
  9. Processing and Templating of Bioactive-loaded Polymeric Neural Architectures: Challenges and Innovative Strategies, Viness Pillay, Pradeep Kumar, Yahya E. Choonara, Girish Modi, Dinesh Naidoo and Lisa C. du Toit, In: Recent Advances in Novel Drug Carrier Systems, Editor: José L. Arias. Published, InTech Publisher, Pages 355-392, ISBN 979-953-307-1092-8, 2012.
  10. Legislative measures for in vitro/in vivo correlations and pharmacokinetic modelling, Viness Pillay, Yahya E. Choonara, Pradeep Kumar, Valence M. K. Ndesendo, Lisa C. du Toit, In: Patenting nanomedicines, Editor: Eliana B. Souto, Springer, Pages: 49-96, ISBN: 978-3-642-29264-4. (Available: http://www.springer.com/law/book/978-3-642-29264-4), 2012.
  11. Crosslinked-Alginates for Modified Drug Delivery Applications: A Molecular Mechanistic Revisit, Viness Pillay, Pradeep Kumar, Yahya E. Choonara and Lisa C. du Toit, In: Alginates: Production, Types and Applications,   Editor: Manuel E. Molina and Andres J. Quiroga, Nova Science Publishers, Inc., ISBN: 978-1-61942-546-0, pp. 123-150, 2012.
  12. Overview and Approaches Employed to Design Innovative Drug Delivery Systems for the Prophylaxis of HIV/AIDS and Prevention of STIs, Viness Pillay, Valence M. K. Ndesendo, Yahya E. Choonara, Lisa C. du Toit, Eckhart Buchmann, Leith Meyer and David Bayever, In: Advances in Medicine and Biology,   Editor: Leon V. Berhardt, Nova Science Publishers, Inc., volume 48, Pages 1-62, ISBN: 978-1-61942-300-8, 2012.

 

Conference and Seminar Papers Presented

 

The WADDP has made over 300 oral and poster presentations at recognized international and local peer-reviewed conferences. Below is a representative list of original research findings that were presented since 2011.

  1. Copolymeric Nanoparticle Depot for Prolonged Insulin Delivery in the Diabetic Rabbit, Lomas K. Tomar, Charu Tyagi, Manoj Kumar, Pradeep Kumar, Yahya E. Choonara, Harpal Singh and Viness Pillay, International Conference on Health, Environment and Industrial Biotechnology, BioSangam 2013, Department of Biotechnology, Mortilal Nehru Institute of Technology Allahabad, India, November 21-13, 2013.
  2. Biodegradable Cellulose-g-Glycidyl methacrylate Surfaces for Quantitative Enzyme Linked Immunosorbent Assay, Charu Tyagi, Lomas K .Tomar, Yahya E. Choonara, Harpal Singh and Viness Pillay, International Conference on Health, Environment and Industrial Biotechnology, BioSangam 2013, Department of Biotechnology, Mortilal Nehru Institute of Technology Allahabad, India, November 21-13, 2013.
  3. Electrospun nanofiber matrix with a mucoadhesive backing film for oramucosal drug delivery Charu Tyagi, Clare Dott, Lomas Tomar, Yahya E. Choonara, Lisa C. du Toit, Pradeep Kumar and Viness Pillay, 5th   International Conference on Chemical, Biological and Environmental Engineering – ICBEE 2013 Conference, New Delhi, India, 14-15 September 2013.
  4. Podium Presentation: Rheological and swelling behavior of pH sensitive hydrogel particles, Lomas Kumar Tomar, Charu Tyagi, Yahya E. Choonara, Pradeep Kumar, Lisa C. du Toit and Viness Pillay, 5th  International Conference on Chemical, Biological and Environmental Engineering – ICBEE 2013 Conference, New Delhi, India, 14-15 September 2013.
  5. Podium Presentation: In silico analyticomathematical interpretation of multi(biomed)material assemblies: Quantification of energy surfaces and molecular attributes via atomistic simulations, Pradeep Kumar, Yahya E. Choonara and Viness Pillay, 25th European Conference on Biomaterials, Madrid, Spain, September 8-12th, 2013.
  6. Exploration of a Composite Nano-Medical Device for the Delivery of Neuroprotectant-Nanocarriers into Targeted Neuronal Cells of Alzheimer’s disease. Maluta S. Mufamadi, Yahya E. Choonara, Lisa C. du Toit, Girish Modi, Dinesh Naidoo, Pradeep Kumar, Valence M.K. Ndesendo, Leith C.R Meyer, Sunny E. Iyuke, Viness Pillay. 16th Congress of the European Federation of Neurological Societies (EFNS), Ageing and dementia, Stockholm, Sweden, Europe, September 08 - 11, 2012.
  7. Design, Biomolecular Modeling and Evaluation of Surface-Engineered Nanoliposomes for the Management of Alzheimer’s disease. Maluta S. Mufamadi, Yahya E. Choonara, Lisa C. du Toit, Girish Modi, Dinesh Naidoo, Pradeep Kumar, Valence M.K. Ndesendo, Leith C.R Meyer, Sunny E. Iyuke, Viness Pillay. 16th Congress of the European Federation of Neurological Societies (EFNS), Neurotoxicology/Occupational Neurology, Stockholm, Sweden, Europe, September 08 - 11, 2012.
  8. Physicomechanical Transitions of an Implantable Nano-Enabled Biorobotic Intracranial Device for Alzheimers Disease Management for Validation of In Vivo Behaviour in a Simulated Brain Environment. Maluta S. Mufamadi, Yahya E. Choonara, Lisa C. du Toit, Girish Modi, Dinesh Naidoo, Pradeep Kumar, Valence M.K. Ndesendo, Leith C.R Meyer, Sunny E. Iyuke, Viness Pillay. 16th Congress of the European Federation of Neurological Societies (EFNS), Ageing and dementia, Stockholm, Sweden, Europe, September 08-11, 2012.
  9. Bio-Architecture of an Implantable Nano-Biorobotic Intracranial Device for Optimized CNS Drug Delivery. Maluta S. Mufamadi, Yahya E. Choonara, Lisa C. du Toit, Girish Modi, Dinesh Naidoo, Pradeep Kumar, Valence M.K. Ndesendo, Sunny E. Iyuke, Viness Pillay. Wits Faculty of Health Sciences Research Day & Postgraduate Expo 2012. Wits Medical School, Parktown, JHB, South African. September 19, 2012.
  10. Design, Development and Optimisation of a Novel Neurotherapeutic Intracranial Implantable Composite Device Thiresen Govender, Viness Pillay, Girish Modi, Dinesh Naidoo, Yahya E. Choonara and Lisa C. du Toit Presented at the British and Irish Group for the Study of Personality Disorders (BIGSPD) Conference, Manchester, United Kingdom, March 2012.
  11. Novel Approaches to Personality Disorder Treatment: Design of Dual-Acting Nanoparticles for the Enhanced Neurotherapy of Borderline Personality Disorder Thiresen Govender, Nabeela Bhabha, Viness Pillay, Girish Modi, Dinesh Naidoo, Yahya E. Choonara and Lisa C. du Toit Presented at the British and Irish Group for the Study of Personality Disorders (BIGSPD) Conference, Manchester, United Kingdom, March 2012.
  12. Advances in Neurotherapeutics: Intracranial Implantation of a Novel Optimised Polymeric Composite in the New Zealand White Rabbit Cadaver Thiresen Govender, Viness Pillay, Girish Modi, Dinesh Naidoo, Yahya E. Choonara, Lisa C. du Toit and Leith Meyer Presented at the British and Irish Group for the Study of Personality Disorders (BIGSPD) Conference, Manchester, United Kingdom, March 2012.
  13. Fabrication and Evaluation of Camptothecin-loaded Nano-liposomes for the Targeted Treatment of Ovarian Cancer, Derusha Frank, Pradeep Kumar, Lisa C du Toit, Yahya E Choonara, Clement Penny, Viness Pillay, NanoBio 2012 Conference, Villa Ponti, Varese, Lombardy, Italy, 18-20 June 2012.
  14. Formulation, optimization and characterization of mucin-pectin-polyethylene glycol microspheres for intravaginal anti-HIV-1 drug delivery, Felix Mashingaidze, Viness Pillay, Yahya E. Choonara, Lisa C. du Toit, Vinesh Maharaj, Eckhart Buchmann, Valence M.K. Ndesendo and Pradeep Kumar, PharmSci 2012 Conference: The Science of Medicines, East Midlands Conference Centre, Nottingham, United Kingdom, 12 - 14 September 2012.
  15. Polyphenol-Flavonol synergistic paradigm for neural repair: combinatorial computational modeling approach for post-traumatic μ-calpain inactivation, Pradeep Kumar, Viness Pillay, Yahya E. Choonara, Girish Modi, Dinesh Naidoo and Lisa C. du Toit, 7th World Congress for NeuroRehabilitation Congress (WCNR): Innovations in NeuroRehabilitation, Melbourne Convention & Exhibition Centre, Melbourne, Victoria, Australia, 16–19 May 2012. 
  16. Podium Presentation: Image processing and analysis to investigate the morphological design parameters for the fabrication of nanofibrous and macroporous polymeric scaffolds, Pradeep Kumar, Viness Pillay, Yahya E. Choonara, Lisa C. du Toit, Girish Modi, Dinesh Naidoo, 36th Annual South African Numerical and Applied Mathematics Conference, Professional Development Hub, University of the Witwatersrand, Johannesburg, Gauteng, South Africa, 02-04 April, 2012.
  17. In silico theoretical molecular modeling for Alzheimer’s disease: The nicotine-curcumin paradigm in neuroprotection and neurotherapy, Pradeep Kumar, Viness Pillay, Yahya E. Choonara, Girish Modi, Dinesh Naidoo and Lisa C. du Toit, 19th Biennial Meeting of the International Society for Developmental Neuroscience - ISDN2012: Neurodevelopment and Neurological diseases, Tata Institute of Fundamental Research, Mumbai, Maharashtra, India, 11-14 January, 2012.
  18. Podium Presentation: Engineering multifunctional nanoconstructs for spinal cord injury intervention: Nanomicelles-enclatherated nanofibriller implants mimicking the nanophysicomechanical properties of spinal cord, Pradeep Kumar, Dinesh Naidoo, Girish Modi, Yahya E. Choonara, Viness Pillay, 22nd Biennial Congress of the Society of Neurosurgeons of South Africa, Lord Charles Hotel, Western Cape, South Africa, 4-6 October, 2012. [Abstract accepted for oral presentation]
  19. Multifunctional Nanoconstructs- Enclatherated Nanoporous Implants for Spinal Cord injury Intervention: Mimicking the Nanophysicomechanical Properties of Spinal Cord, Pradeep Kumar, Yahya E. Choonara, Girish Modi, Dinesh Naidoo, Viness Pillay, 10th Biennial Southern African Spinal Cord Association Congress, The Pavilion Conference Centre, V & A Waterfront, Cape Town, South Africa, 22-24 November, 2012.
  20. In Vivo Verification of the Bioresponsive Potential of an Intelligent Intraocular Implant, Lisa C. Du Toit, Viness Pillay, Thirumala Govender, Trevor Carmichael and Yahya E. Choonara, Association for Research in Vision and Ophthalmology (ARVO) Annual Meeting 2012, Fort Lauderdale Florida, USA, 6-10 May 2012.
  21. Effect of polymer functionalization and crosslinking on the design of novel spinomimetic cryosponges: A mechanotransduction approach for enhanced neuronal anchoring, Pradeep Kumar, Viness Pillay, Yahya E. Choonara, Lisa C. du Toit, Girish Modi and D. Naidoo, 4th International Conference on the Mechanics of Biomaterials and Tissues, Marriott Waikola Beach Resort and Spa, Hawai’i, USA, 11-14 December 2011.
  22. Robust design of biodegradable block-copoly(ester-ether)s and multifunctional nanoconstructs for spinal cord injury intervention: Cellular uptake and nano-neuro-sealing of disrupted neuronal membranes, Pradeep Kumar, Viness Pillay, Yahya E. Choonara, Lisa C. du Toit, Girish Modi and D. Naidoo, Dhanjay Jhurry, Yaman Lochee, Archana Bhaw-Luximon, 2nd Nano Today Conference 2011, Marriott Waikola Beach Resort and Spa, Hawai’i, USA, 11-15 December 2011.
  23. Quantification of energy surfaces and molecular attributes for emulsified polymeric systems: An in silico analytico-mathematical interpretation of novel surfactant-electrolyte-stabilized nanoparticulate assemblies, Pradeep Kumar, Viness Pillay, Yahya E. Choonara, Lisa C. du Toit, 2nd Nano Today Conference 2011, Marriott Waikola Beach Resort and Spa, Hawai’i, USA, 11-15 December 2011.
  24. Hierarchically micro-meso-macroporous PLGA/PCL scaffolds for neural tissue engineering, Pradeep Kumar, Viness Pillay, Yahya E. Choonara, Lisa C. du Toit, Girish Modi and D. Naidoo, 2nd International symposium Frontiers in Polymer Science 2011, Lyon, France, in association with journal Polymer, 29-31 May 2011.
  25. The development of an in situ forming implant for the treatment of solid tumors: Determination of the effect of methotrexate release on colon carcinoma cells and in vivo studies in the rat model, Ameena Wadee, Viness Pillay, Yahya E. Choonara, Lisa C. du Toit and Clement Penny, 6th International Conference on Pharmaceutical and Pharmacological Sciences (ICPPS), Durban, South Africa, 25-27 September, 2011.
  26. Design and characterization of intravenously administered nanolipobubbles for targeted ovarian cancer therapy, Derusha Frank, Viness Pillay, Yahya E. Choonara and Lisa C. u Toit, 6th International Conference on Pharmaceutical and Pharmacological Sciences (ICPPS),  Durban, South Africa, 25-27 September,  2011.
  27. Evaluation of the physicochemical and physicomechanical properties of optimized ciprofloxacin- and diclofenac-loaded co-blended alginate fibers for oramucosal delivery, Deanne Hazel, Viness Pillay and Michael P. Danckwerts, 6th International Conference on Pharmaceutical and Pharmacological Sciences (ICPPS),  Durban, South Africa, 25-27 September,  2011.
  28. Elucidation of the effect of oxidation and crosslinking on the drug entrapment efficiency and in vitro drug release behaviour of a starch-based multiparticulate drug delivery system, Yusuf Dawood, Pradeep Kumar, Viness Pillay, Yahya E. Choonara and Lisa C. du Toit, 6th International Conference on Pharmaceutical and Pharmacological Sciences (ICPPS),  Durban, South Africa, 25-27 September,  2011.
  29. In vivo determination of the bioresponsive potential of an intelligent intraocular implant, Lisa du Toit, Viness Pillay, Thirumala Govender, Trevor R. Carmichael and Yahya E. Choonara, School of Therapeutic Sciences Research Day, University of the Witwatersrand, August 24, 2011.
  30. Development of chlorpromazine-loaded, polycaprolactone based nanoparticles utilizing a novel melt-dispersion technique, Thiresen Govender, Viness Pillay, Yahya E. Choonara, Lisa C.du Toit, Girish Modi and Dinesh Naidoo, School of Therapeutic Sciences Research Day, University of the Witwatersrand, August 24, 2011.
  31. A novel oral ghost drug delivery device for the injection free administration of salmon calcitonin, Angus Hibbins, Viness Pillay, Yahya E. Choonara, Lisa C. du Toit and Pradeep Kumar, School of Therapeutic Sciences Research Day, University of the Witwatersrand, August 24, 2011.
  32. In silico theoretical molecular modeling for Alzheimer’s disease: The nicotine-curcumin paradigm in neuroprotection and neurotherapy, Pradeep Kumar, Viness Pillay, Yahya E. Choonara, Girish Modi, Dinesh Naidoo and Lisa C. du Toit, School of Therapeutic Sciences Research Day, University of the Witwatersrand, August 24, 2011.
  33. An implantable nano-enabled bio-robotic intracranial device for the delivery of anti-aging drug in Alzheimer’s disease, Maluta S. Mufamadi, Viness Pillay, Yahya E. Choonara, Lisa C. du Toit, Girish Modi, Dinesh Naidoo, Leith C.R Meyer and Sunny E. Iyuke, School of Therapeutic Sciences Research Day, University of the Witwatersrand, August 24, 2011.
  34. Pectin-mucin interactions: Implication and application in microsphere formulation for drug delivery, Felix Mashingaidze, Viness Pillay, Yahya E. Choonara, Vinesh Maharaj and Lisa C. du Toit, School of Therapeutic Sciences Research Day, University of the Witwatersrand, August 24, 2011.
  35. Fabrication and characterizations of an implantable nano-enabled Biorobotic Intracranial Device for enhance drug delivery into targeted neuronal cells of Alzheimer’s disease, Maluta Steven Mufamadi, Viness Pillay, Yahya E. Choonara, Lisa C. Du Toit, Girish Modi, Dinesh Naidoo, Leith C.R Meyer and Sunny E. Iyuke, AAPS Annual Meeting & Exposition, Washington Convention Center, Washington, DC, USA, 23-27 October, 2011.
  36. Formulation and physicochemical characterization of surface-modified nanoliposomes by chelating ligands, Maluta Steven Mufamadi, Viness Pillay, Yahya E. Choonara, Lisa C. Du Toit, Girish Modi, Dinesh Naidoo, Leith C.R Meyer and Sunny E. Iyuke, AAPS Annual Meeting & Exposition, Washington Convention Center, Washington, DC, USA, 23-27 October, 2011.
  37. Surface-modified nanoliposomes by chelating ligands modulates neurotoxicity associated with beta amyloid aggregation, Maluta Steven Mufamadi, Viness Pillay, Yahya E. Choonara, Lisa C. du Toit, Girish Modi, Dinesh Naidoo, Leith C.R Meyer and Sunny E. Iyuke, AAPS Annual Meeting & Exposition, Washington Convention Center, Washington, DC, USA, 23-27 October, 2011.
  38. Development of functionalized nanoliposomes using Box-Behnken experimental design validate improvement of galantamine uptake by neuronal cells, Maluta Steven Mufamadi, Viness Pillay, Yahya E. Choonara, Lisa C. du Toit, Girish Modi, Dinesh Naidoo, Leith C.R Meyer and Sunny E. Iyuke, AAPS Annual Meeting & Exposition, Washington Convention Center, Washington, DC, USA, 23-27 October, 2011.
  39. Elucidation of the cytotoxicity and intracellular uptake of a surface modified nanoliposomes by a chelating ligands, Maluta Steven Mufamadi, Viness Pillay, Yahya E. Choonara, Lisa C. du Toit, Girish Modi, Dinesh Naidoo, Leith C.R Meyer and Sunny E. Iyuke, AAPS Annual Meeting & Exposition, Washington Convention Center, Washington, DC, USA, 23-27 October, 2011.
  40. A triple-mechanism gastroretentive system for sustained delivery of levodopa, Ndidi C. Ngwuluka, Viness Pillay, Girish Modi, Dinesh Naidoo, Yahya E. Choonara and Lisa C. du Toit, 38th Annual Meeting & Exposition of the Controlled Release Society (CRS), Gaylord National Hotel and Convention Center, National Harbor, Maryland, USA, July 30 - August 3, 2011.
  41. Application of ligand-functionalize nanoliposomes to reduce the neurotoxicity associated with β-amyloid aggregation in Alzheimer’s disease, Maluta Steven Mufamadi, Viness Pillay, Yahya E. Choonara, Lisa C. du Toit, Girish Modi, Dinesh Naidoo, Leith C.R Meyer and Sunny E. Iyuke, 6th International Conference on Pharmaceutical and Pharmacological Sciences (ICPPS), Durban, South Africa, 25-27 September,  2011.
  42. An implantable nano-enabled Biorobotic Intracranial Device for neurotherapeutic applications, Maluta Steven Mufamadi, Viness Pillay, Yahya E. Choonara, Lisa C. du Toit, Girish Modi, Dinesh Naidoo, Leith C.R Meyer and Sunny E. Iyuke, 6th International Conference on Pharmaceutical and Pharmacological Sciences (ICPPS), Durban, South Africa, 25-27 September,  2011.
  43. An Electro-Rheological Fluid as a responsive Implant for Controlled Stimuli-Liberation of Diclofenac Sodium. Valence M. K. Ndesendo, Viness Pillay, Yahya E. Choonara, Refilwe B. Mosane, Pradeep Kumar and Lisa C. du Toit. [P.3.109] 2nd International symposium Frontiers in Polymer Science 2011, in association with journal POLYMER. 29-31 May 2011, Lyon, France.
  44. Robust design of biodegradable block-poly(ester-ether)s and multifunctional nanoconstructs for spinal cord injury intervention: Cellular uptake and nano-neuro-sealing of disrupted neuronal membranes, Pradeep Kumar, Viness Pillay, Yahya E. Choonara, Lisa C. du Toit, Girish Modi, Dinesh Naidoo, R. Jeetah, Y. Lochee, A. Bhaw-Luximon, Dhanjay Jhurry, 4th International Conference on the Mechanics of Biomaterials and Tissues, Frontiers in Polymer Science, Centre de congrès, Lyon, France, 29-31 May, 2011.
  45. Invited Plenary Speaker: Overview of the Preclinical Phase of Drug Delivery Technologies Developed at the Wits Drug Delievry Platform:  A Case for Technology Transfer and Commercialization, Viness Pillay, Yahya E. Choonara and, Lisa C. du Toit, 17th Scientific Meeting of the South African Association for Laboratory Animal Science (SAALAS), University of the Witwatersrand, Johannesburg, South Africa, 9-11 March 2011.
  46. Invited Keynote Speaker: In Vivo Evaluation of Novel Implantable Drug Delivery Technologies for Penetration of Restrictive Physiological Barriers, Viness Pillay, Yahya E. Choonara and Lisa C. du Toit, 17th Scientific Meeting of the South African Association for Laboratory Animal Science (SAALAS), University of the Witwatersrand, Johannesburg, South Africa, 9-11 March 2011.
  47. Invited Keynote Speaker: Preclinical Investigation of Novel Site-Specific Drug Delivery Technologies for Admisitration in the Large White Pig Model:  A Surrogate for Human Studies, Viness Pillay, Lisa C. du Toit and Yahya E. Choonara, 17th Scientific Meeting of the South African Association for Laboratory Animal Science (SAALAS), University of the Witwatersrand, Johannesburg, South Africa, 9-11 March 2011.
  48. Invited Key Note Speaker: A smart composite polymeric scaffold for neural tissue engineering, Viness Pillay and Yahya E. Choonara, 40th South African Chemical Institute (SACI) National Convention and the 3rd Federation of African Chemical Societies (FASC) Meeting: A Prelude Event to the International Year of Chemistry SACI 2011, First National Bank Building West Campus, University of the Witwatersrand, Johannesburg, South Africa, 16-21 January 2011.

 

Patents

 

The WADDP has amassed over 35 PCT quality patents in the field of advanced drug delivery technology. Several patents have been geographically granted and many are currently under prosecution in the USA, UK, Europe, Japan and South Africa. Below is a representative list of patents that have been filed from original research emanating from the WADDP laboratories.

 

  1. Monolithic Tablet for Controlled Drug Release, United States Patent # 6,090,411, Viness Pillay and Reza Fassihi, Granted 18 July 2000.
  2. Compressed composite delivery system for release-rate modulation of bioactives, Reza Fassihi and Viness Pillay, United States Patent Application 20060024368, Filed on February 02, 2006.
  3. Oramucosal pharmaceutical dosage form, R. Patel, V. Pillay, M.P. Danckwerts, SA granted 24.06.2009, PCT Filed (PCT/IB2006/02585, Publ 29.03.2007 WO 2007/034287), National applications filed in US, Japan, and Europe.
  4. Biodegradable implantable drug delivery device, Y.E. Choonara, V. Pillay, M.P. Danckwerts, National applications filed in US.
  5. A polyamide rate-modulated monolithic drug delivery system, O.A. Kolawole V. Pillay, Y.E. Choonara, PCT filed (PCT/IB2008/000395) (Publ 28.08.2008 WO2008/102247) and SA complete granted 29.07.2009 (SA2008/01723). National applications filed in US, Europe, and Japan.
  6. A Heterogeneously configured multiparticulate gastrointestinal drug delivery system, M.P. Danckwerts, L.C. du Toit, V. Pillay, Y.E. Choonara, S. Cooppan, PCT filed (PCT/IB2007/003727) (Publ 28.06.2008 WO2008/068584), SA Complete granted 29.10.2008 (SA 2007/10786). National applications filed in US and Europe.
  7. S. Sibambo, V. Pillay, Y.E. Choonara, An improved monolithic drug delivery system, PCT filed (PCT/IB2008/000396) (Publ 28.08.2008 WO2008/102248), SA complete granted on 29.07.2009 (SA 2008/01724) and Japan complete granted on 11.01.2013 (Jap Patent 517847). National applications filed US and Europe.
  8. Pharmaceutical dosage form for the site-specific delivery of more than one active pharmaceutical ingredient, P. Bawa, V. Pillay, Y.E. Choonara, PCT (PCT/IB2009/005830) (Publ 23.12.2009 WO 2009/153633) and SA granted 25.04.2012 (SA 2009/03858). National applications filed in US, Japan and Europe.
  9. A gastroretentive pharmaceutical dosage form, S. Moonisami, V. Pillay, Y.E. Choonara, C. Murphy, PCT (PCT/IB2009/005828) (Publ 23.12.2009 WO 2009/153632) and SA granted 23.02.2011 (SA 2009/03854). National applications filed in US, Japan, and Europe.
  10. A chronotherapeutic pharmaceutical dosage form, S. Sewlall, V. Pillay, Y.E. Choonara, Z. Kahn, PCT (PCT/IB2009/005832) (Publ 23.12.2009 WO 2009/153635) and SA complete granted 25.01.2012 (SA 2009/03855). National applications filed in US, Japan and Europe.
  11. A transmucosal delivery system, D. Reddy, V. Pillay, Y.E. Choonara, PCT filed (PCT/IB2009/005831) (Publ 3.12.2009 WO 2009/153634) and SA Complete granted 28.12.2011 (SA 2009/03857). National applications filed in US, Japan and Europe.
  12. A controlled release intravaginal polymeric pharmaceutical, V.M.K. Ndesendo, V.Pillay Y.E. Choonara, PCT filed (PCT/IB2009/007583) (Publ 03.06.2010 WO2010/06124). National applications filed in SA and ARIPO.
  13. Polymeric pharmaceutical dosage form in sustained release applications, V. Pillay, S. Pillay, B. Sibeko, S. Harilall, D. Naidoo and G. Modi, PCT filed (PCT/IB2009/007598) (Publ 03.06.2010 WO/2010/061288) and SA granted (SA 2009/08493). National applications filed in US and Europe.
  14. Development of a matrix for transmucosal drug delivery, O.A. Kolawole, V. Pillay, Y.E. Choonara, Provisional filed (SA 2008/09707).          
  15. A pharmaceutical composition, P.S. Fasinu, V. Pillay, Y.E. Choonara, L.C. du Toit, PCT filed (PCT/IB2011/055337) (Publ 31.05.2012 WO 2012/070030), National application filed in the US.
  16. Polymeric matrix of polymer-lipid nanoparticles as a pharmaceutical dosage form, N. Ngwuluka, V. Pillay Y.E. Choonara, L.C. du Toit, PCT filed (PCT/IB2011/055340) (Publ 31.05.2012 WO 2012/070031). National applications filed in Europe, US, China, Japan and SA.
  17. A pharmaceutical dosage form, R.P. Shaikh, V. Pillay, Y.E. Choonara, L.C. du Toit, PCT filed (PCT/IB2011/055331) (Publ 31.05.2012 WO 2012/070028). National applications filed in Europe, US, China, Japan, India and SA.
  18. A drug delivery device, T. Govender, S. Mufamadi, V. Pillay, Y.E. Choonara, L.C. du Toit, G. Modi, D. Naidoo, PCT filed (PCT/IB2011/055345) (Publ 31.05.2012 WO 2012/070034). National applications filed in Europe, US, China, Japan, India and SA.
  19. Pharmaceutical dosage form, K. Moodley, V. Pillay, Y.E. Choonara, L.C. du Toit, complete application accepted, SA granted 27.02.2013 (SA 2012/01424).     
  20. An implant for controlled release of drugs, A. Wadee, V. Pillay, Y.E. Choonara, L.C. du Toit, (PCT/IB2011/055343) (Publ 31.05.2012 WO 2012/070033), National applications filed in US, Europe and SA.        
  21. Polymeric hydrogel compositions which release active agents in response to Electrical Stimulus, T. Tsai, V. Pillay, Y.E. Choonara, L.C. du Toit, PCT filed (PCT/IB2011/055322) (Publ 31.05.2012 WO 2012/070026), National application filed in US.     
  22. A drug delivery device, L.C. du Toit, V. Pillay, Y.E. Choonara, T. Govender, T.R. Carmichael, PCT filed (PCT/IB2011/055328) (Publ 31.05.2012 WO2012/070027). National applications filed in US, Europe, China, ARIPO, India, Brazil and SA.
  23. A pharmaceutical composition, N. Chirwa, V. Pillay, Y.E. Choonara, P. Kumar, L.C. du Toit, PCT filed (PCT/IB2011/055332) (Publ 31.05.2012 WO2012/070029). National applications filed in US, Europe, China, ARIPO, India and SA.
  24. A polymer-engineered neural device, P. Kumar, V. Pillay, Y.E. Choonara, L.C. du Toit, G. Modi, D. Naidoo, Provisional application filed 12.10.2011 (SA 2010/07277).     
  25. An implantable device for targeted and prolonged drug delivery, S. Mufamadi, V. Pillay, Y.E. Choonara, G. Modi, D. Naidoo, L.C. du Toit, Provisional application filed (SA 2010/07276).
  26. A pharmaceutical dosage form, Y.E. Choonara, L.C. du Toit, P. Kumar, V. Pillay, R.M. Moosa, R. Jhetam, PCT application filed (PCT/IB2013/058453).   
  27. Pharmaceutical dosage form, P. Kumar, V. Pillay, Y.E. Choonara, PCT application filed 11.09.2013 (PCT/IB2013/058458).
  28. Liposomal drug delivery system, D. Frank, V. Pillay, L.C. du Toit, Y.E. Choonara, PCT filed (PCT/IB2013/059116),, National applications, 30 month countries 04.04.2015.
  29. Oral pharmaceutical dosage form, A.R. Hibbins, V. Pillay, Y.E. Choonara, L.C. du Toit, P. Kumar, Provisional application filed (SA 2012/07430).   
  30. Probiotic drug delivery system, M. Govender, V. Pillay, Y.E. Choonara, P. Kumar, L.C. du Toit, Provisional application filed (SA 2013/03979).           
  31. An implantable sensor for disease prevention and treatment, M.P. Ngoepe, V. Pillay, Y.E. Choonara, P. Kumar, L.C. du Toit, Provisional application filed (SA 2013/03981).          
  32. The use of microneedle arrays for efficient and painless administration of bioactives through the skin, S. Indermun, V. Pillay, Y.E. Choonara, P. Kumar, L.C. du Toit, Provisional application filed (SA 2013/03983).
  33. Xerogel based oral delivery system, F.G. Hoosain, V. Pillay, Y.E. Choonara, P. Kumar, L.C. du Toit, Provisional application filed (SA 2013/03984).
  34. Resorbable wound dressings, N. Mayet, V. Pillay, Y.E. Choonara, P. Kumar, L.C. du Toit, Provisional application filed (SA 2013/03982).
  35. pH-responsive oral polymeric pharmceutical dosage form, P.P.D. Kondiah, V. Pillay, Y.E. Choonara, G. Modi, L.C. du Toit, P.Kumar, L.K. Tomar, C. Tyagi, Provisional application filed (SA 2013/05584).
  36. Nanoparticulate system for intracellular drug delivery, L. Singh, V. Pillay, Y.E. Choonara, L.C. du Toit, P. Kumar, Provisional application filed (SA 2013/03980).

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