Cardiovascular Pathophysiology and Genomics Research Unit
About the Research Group
The CPGRU is a university-recognised research unit with strong collaborations across clinical departments, including a satellite unit at Life Flora Hospital. The unit produces approximately 25–30 publications annually and graduates multiple MSc and PhD students. The vision of CPGRU is to be a leading research unit transforming cardiovascular health outcomes in Sub-Saharan Africa by pioneering new multidisciplinary knowledge and fostering innovations for early detection, effective prevention, and improved therapeutic approaches to cardiovascular diseases, in all adults with a specific focus on young adults.
Research focuses on identifying mechanisms underlying cardiovascular disease to guide prevention and treatment strategies. Key areas include:
- Aortic dysfunction
- Hypertension
- Diabetes mellitus
- Obesity
- Chronic inflammation (e.g. rheumatoid arthritis)
- HIV-associated cardiovascular disease
The unit also contributes to understanding vascular disease, chronic kidney disease, heart failure, and sex and ethnic differences in cardiovascular risk. A distinguishing feature is its integration of basic science and clinical research approaches.
Staff Involved
Professor Angela Woodiwiss (Director) (Angela.Woodiwiss@wits.ac.za)
Associate Professor Vernice Peterson
Dr Glenda Norman
Dr Grace Tade
Dr Andrea Kolkenbeck-Ruh
Dr Nonhlanhla Mthembu
Mr Ngwanamadima Mapheto