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Original Publications


1. Müller, B., Restle, T., Weiss, S., Gautel, M., Sczakiel, G. and Goody, R.S. (1989) Co-expression of the subunits of the heterodimer of HIV-1 Reverse Transcriptase in Escherichia coli. J.Biol.Chem. 264, 13975-13978

2. Auer, M., Krieger, C., Gautel, M., Labeit, S., Sczakiel, G., Weiss, S. and Goody, R.S. (1989) Synthesis and biological Applications of 2'3' Dideoxynucleoside-5'-O-(α-Thio) Triphosphates. Nucleosides and Nucleotides, 8, 849-853 (now Nucleosides, Nucleotides & Nucleic Acids)

3. Weiss, S., König, B., Müller, H.-J., Seidel, H. and Goody, R.S. (1992) Synthetic human tRNALys3 and natural bovine tRNALys3 interact with HIV-1 reverse transcriptase and serve as specific primers for retroviral cDNA synthesis. Gene, 111, 183-197

4. Weiss, S., König, B., Murikawa, Y., Jones, I. (1992) Recombinant HIV-1 Nucleocapsid protein p15 produced as a fusion protein with glutathione S-transferase in Escherichia coli mediates dimerization and enhances reverse transcription of retroviral RNA. Gene, 121, 203-212

5. Weiss, S., Häusl, G., Famulok, M. and König, B. (1993) The multimerization state of retroviral RNA is modulated by ammonium ions and affects HIV-1 full-length cDNA synthesis in vitro. Nucleic Acids Res., 21, 4879-4885

6. Weiss S., Famulok, M., Edenhofer, F., Wang, Y.-H., Jones I.M., Groschup, M. and Winnacker, E.-L. (1995) Overexpression of Active Syrian Golden hamster prion protein PrPc as a glutathione S-transferase fusion in heterologous systems. J. Virol.69, 4776-4783

7. Weiss, S., Rieger, R., Edenhofer, F., Fisch, E. and Winnacker, E.-L. (1996) Recombinant prion protein rPrP27-30 from Syrian Golden Hamster reveals proteinase K sensitivity. Biochem. Biophys. Res. Commun., 219, 173-179

8. Edenhofer, F., Rieger, R., Famulok, M., Wendler, W., Weiss, S. and Winnacker, E.-L. (1996) Prion Protein PrPc interacts with Molecular Chaperones of the Hsp60 Family. J. Virol., 70, 4724-4728

9. Weiss, S., Proske, D., Neumann, M., Groschup, M.H., Kretzschmar, H.A., Famulok, M. and Winnacker, E.-L. (1997) RNA aptamers specifically interact with the prion protein PrP. J. Virol., 71, 8790-8797

10. Rieger, R., Edenhofer, F., Lasmézas, C.I. and Weiss, S. (1997) The Human 37 kDa laminin receptor precursor interacts with prion protein in eucaryotic cells. Nature Medicine, 3, 1383-1388 (Comment by Alison Mitchell: Puzzeling over prion partners. 1997. Nature Medicine 3, 1322)

11. Gauczynski, S., Peyrin, J.-M., Haïk, S., Leucht, C., Hundt, C., Rieger, R.,Krasemann, S., Deslys, J.-P., Dormont, D., Lasmézas, C.I. and Weiss, S. (2001) The 237 kDa/67 kDa laminin receptor acts as the cell surface receptor for the cellular prionprotein. The EMBO Journal, 20, 5863-5875 (illustrated by the cover of this issue) (published back to back with (12.)

12. Hundt, C., Peyrin, J.-M., Haïk, S., Gauczynski, S., Leucht, C., Rieger, R.,Riley, M.-L., Deslys, J.-P., Dormont, D., Lasmézas, C.I. and Weiss, S. (2001) Identification of interaction domains of the prion protein with its 37 kDa/67 kDalaminin receptor. The EMBO Journal. 20, 5876-5886 (illustrated by the cover of this issue) (published back to back with (11.)

13. Riley, M.-L., Leucht, C., Gauczynski, S., Hundt, C., Brecelj, M., Dodson, G.and Weiss, S. (2002) High-level expression and characterisation of a glycosylated covalently linked dimer of the prion protein. Prot. Eng. (Design & Selection) 15, 529-537

14. Warner, R.G., Hundt, C., Weiss, S. and Turnbull, J.E. (2002) Identification of heparan sulfate binding sites in the cellular prion protein. J. Biol. Chem. 277, 18421-18430

15. Gauczynski, S., Krasemann, S., Bodemer, W. and Weiss, S. (2002) Recombinant human prion protein mutants huPrPD178N/M129 (FFI) and huPrP 9OR (fCJD) reveal proteinase K resistance. Journal of Cell Science, 115,4025-4036

16. Leucht, C., Simoneau, S., Rey, C., Vana, K., Rieger, R., Lasmézas, C.I. and Weiss, S. (2003) The 37 kDa/67 kDa laminin receptor is required for PrPSc propagation in scrapie-infected neuronal cells. EMBO Reports, 4, 290-295 [Erratum published EMBO reports, 4, 439, 2003]

17. Hundt, C., Gauczynski, S., Leucht., C., Riley, M.-L. and Weiss, S. (2003) Intra- and interspecies interactions of prion proteins and effects of mutations and polymorphisms. Biological Chemistry, 384, 791-803

18. Simoneau, S., Haïk, S., Leucht, C., Dormont, D., Deslys, J.-P., Weiss, S. and Lasmézas, C.I. (2003) Different Isoforms of the Non-Integrin Laminin Receptor are Present in Mouse Brain and Bind PrP. Biological Chemistry, 384, 243-246

19. Leucht, C., Vana, K., Renner-Müller, I., Lasmézas, C.I., Wolf E. and Weiss S. Knock-down of the 37-kDa/67-kDa laminin receptor in mouse brain by transgenic expression of specific antisense LRP RNA. 2004. Transgenic Research, 13, 81-85

20. Hundt, C. and Weiss, S. The prion-like protein Doppel fails to interact with itself, the prion protein and the 37 kDa/67 kDa laminin receptor in the yeast two hybrid system (Rapid report). 2004. Biochim Biophys Acta – Molecular Basis of Disease, 1689, 1-5

21. Baloui, H., Von Boxberg, Y., Vinh, J., Weiss, S., Rossier, J., Nothias, F. and Stettler, O. Cellular prion protein/laminin receptor: Distribution in adult central nervous system and characterization of an isoform associated with a subtype of corticalneurons. 2004. European Journal of Neuroscience, 20, 2605-26163

22. Morel, E., Andrieu, T., Casagrande, F., Gauczynski, S., Weiss, S., Grassi, J.,Rousset, M., Dormont, D. and Chambaz, J. Bovine prion is endocytosed by human enterocytes via the 37 kDa/67 kDa laminin receptor. 2005. American Journal of Pathology, 167 (4), 1033-1042

23. Vana, K. and Weiss, S. A trans-dominant negative 37 kDa/67 kDa laminin receptor mutant impairs PrPSc propagation in scrapie-infected neuronal cells. 2006. Journal of Molecular Biology, 358, 57-66

24. Gauczynski, S., Nikles, D., El-Gogo, S., Papy-Garcia, D., Rey, C., Alban, S., Barritault, D., Lasmézas, C.I. and Weiss, S. The 37 kDa/67 kDa laminin receptor acts as a receptor for infectious prions and is inhibited by polysulfated glycanes. 2006. Journal of Infectious Diseases, 194, 702-709 (illustrated by the cover of this issue)

25. Zuber, C., Mitteregger, G., Pace, C., Zerr, I., Kretzschmar, H.A. and Weiss, S. Anti-LRP/LR antibody W3 hampers peripheral PrPSc propagation in Scrapie infected mice. 2007. Prion, 1 (3), 207-212

26. Zuber, C., Knackmuss, S., Rey, C., Reusch, U., Röttgen, P., Fröhlich, T., Arnold, G.J., Pace, C., Mitteregger, G., Kretzschmar, H.A., Little, M. and Weiss, S. Single chain Fv antibodies directed against the 37kDa/ 67kDa laminin receptor as therapeutic tools in prion diseases. 2008. Molecular Immunology, 45, 144-151

27. Zuber, C., Knackmuss, S., Zemora, G., Reusch, U., Vlasova, E., Diehl, D., Mick, V., Hofmann, K., Nikles, D., Fröhlich, T., Arnold, G., Brenig, B., Wolf, E., Lahm, H., Little, M. and Weiss, S. Invasion of tumorigenic HT1080 cells is impeded by downregulating or blocking the 37kDa/67kDa laminin receptor. 2008. J. of Molecular Biology, 378, 530-539

28. Nikles, D., Vana, K., Gauczynski, S., Knetsch, H., Ludewigs, H. and Weiss, S.Subcellular localization of prion proteins and the 37 kDa/67 kDa laminin receptor fused to fluorescent proteins. 2008. Biochimica Biophysica Acta – Molecular Basis of Disease, 1782, 335-340

29. Zuber, C., Mitteregger, G., Schuhmann, N., Rey, C., Knackmuss, S., Rupprecht, W., Reusch, U., Pace, C., Little, M., Kretzschmar, H.A., Hallek, M., Büning, H. and Weiss, S. Delivery of single-chain antibodies scFvs directed against the 37 kDa/67 kDa laminin receptor into murine brain via recombinant Adenoassociated viral vectors for prion disease gene therapy. 2008. J. Gen. Virol., 89, 2054-2060

30. Baloui, H., Stettler, O., Weiss, S., Nothias, F. and von Boxberg, Y.Upregulation in rat spinal cord microglia of the nonintegrin laminin receptor 37 kDa-LRP following activation by a traumatic lesion, or peripheral injury. 2009. J. of Neurotrauma, 26, 195-207.

31. Pflanz, H., Vana, K., Mitteregger, G., Pace, C., Messow, D., Sedlaczek, C., Nikles, D., Kretzschmar, H.A. and Weiss, S. Microinjection of lentiviral vectors expressing siRNAs directed against laminin receptor precursor mRNA prolongs the pre- clinical phase in scrapie-infected mice. 2009. J. Gen. Virol. 90 (1) 269-274.

32. Pflanz, H., Vana. K., Mitteregger, G., Renner-Müller, I., Pace, C.,Küchenhoff, H., Wolf, E., Kretzschmar, H.A. and Weiss, S. Scrapie infected transgenic mice expressing a laminin receptor decoy mutant reveal a prolonged incubation time associated with low levels of PrPres. 2009. J. Mol. Biol. 388, 721-729

33. Kolodziejczak, D., Da Costa Dias, B., Zuber, C., Jovanovic, K., Omar, A., Beck, J., Vana, K., Mbazima, V., Richt, J., Brenig, B., and Weiss, S.F.T. Prion Interaction with the 37-kDa/67-kDa Laminin Receptor on Enterocytes as a Cellular Model for Intestinal Uptake of Prions. 2010. J. Mol. Biol. 402, 293-300.

34. Omar, A., Reusch, U., Knackmuss, S., Little, M. and Weiss, SFT. Anti-LRP/LR specific antibody lgG1-iS18 significantly reuduces adhesion and invasion on metastatic lung, cervix colon and prostate cancer cells. 2012.J. Mol. Biol., 419, 102-109.

35. Moodley K. and Weiss, SFT. Downregulation of the Non-Integrin Laminin Receptor Reduces Cellular Viability by Inducing Apoptosis in Lung and Cervical Cancer Cells. 2013 PLoS ONE 8(3): e57409. doi:10.1371/journal.pone.0057409

36. Khusal, R., Da Costa Dias, B., Moodley, K., Penny, C., Reusch, U., Knackmuss, S., Little, M. And Weiss, S.F.T. In vitro Inhibition of Angiogenesis by antibodies directed against the 37kDa/67kDa Laminin Receptor. 2013 PLoS One, 8(3): e58888.

37. Khumalo, T., Reusch, U., Knackmuss, S., Little, M., Veale, R.B. and Weiss, S.F.T. Adhesion and invasion of breast and oesophageal cancer cells are impeded by anti-LRP/LR-specific antibody IgG1-iS18. 2013, PLoS One, 8(6): e66297.

38. Jovanovic, K., Gonsalves, D., Da Costa Dias, B., Moodley, K.,  Reusch, U., Knackmuss, S., Penny, C., Weinberg, M.S., Little, M., and Weiss, S.F.T. Anti-LRP/LR specific antibodies and shRNAs impede amyloid beta shedding in Alzheimer’s Disease. 2013, Scientific reports, 3, 2699, DOI: 10.1038/srep02699

39. Da Costa Dias, B., Jovanovic, K., Gonsalves, D., Moodley, K.,  Reusch, U., Knackmuss, S., Penny, C., Weinberg, M.S., Little, M., and Weiss, S.F.T. Anti-LRP/LR specific antibody IgG1-iS18 and knock-down of LRP/LR by shRNAs rescue cells from Abeta42 induced cytotoxicity. 2013, Scientific reports, 3, 2702, DOI: 10.1038/srep02702

40. Chetty, C., Khumalo, T., Da Costa Dias, B., Reusch, U.,  Knackmuss, S., Little, M. and Weiss, S.F.T. Anti-LRP/LR specific antibody lgG1-iS18 impedes adhesion and invasion of liver cancer cells. 2014. PLOS One 9(5): e96268 doi: 10.1371/journal.pone.0096268

41. Jovanovic, K., Loos, B.,  Da Costa Dias, B., Penny, C. and Weiss, S.F.T. High resolution imaging study of interactions between the 37kDa/67kDa Laminin Receptor and APP, beta-secretase and gamma-secretase in Alzheimer’s disease. 2014. PLOS One, 9(6): e100373. doi:10.1371/journal.pone.0100373

42. Da Costa Dias, B., Jovanovic, K., Gonsalves, D., Moodley, K., Reusch, U., Knackmuss, S., Weinberg, M.S.,  Little, M. and Weiss, S.F.T. The 37kDa/67kDa Laminin Receptor acts as a receptor for Aβ42 internalization. 2014. Scientific Reports, 4, 5556 doi: 10.1038/srep05556

43. Khumalo, T., Ferreira, E., Jovanovic, K., Veale, R.B. and Weiss, S.F.T. Knockdown of LRP/LR induces apoptosis in breast and oesophageal cancer cells. 2015. PLoS ONE 10(10): e0139584.


 44. Naidoo, K.,  Malindisa, S.T., Otgaar, T.C., Bernert, M., Da Costa Dias, B., Ferreira, E., Reusch, U., Knackmuss, S., Little, M., Weiss, S.F.T. and Letsolo, B.T. Knock-down of the 37kDa/67kDa laminin receptor LRP/LR impedes telomerase activity. 2015.  PLoS One, 10(11):e0141618. doi:10.1371/journal.pone.0141618

45. Pinnock, E.C., Jovanovic, K., Pinto, M.G., Ferreira, E., Da Costa Dias, B., Penny, C., Knackmuss, S., Reusch, U., Little, M., Schatzl, H.M. and Weiss, S.F.T. LRP/LR antibody mediated rescuing of Abeta induced cytotoxicity is dependent on PrPc in Alzheimer’s Disease. 2016. J. Alzheimer’s Disease, 49(3), 645-657. DOI 10.3233/JAD-150482

46.. L. Vania, C.J. Chetty, E. Ferreira and S.F.T Weiss. Anti-LRP/LR specific antibody IgG1-iS18 significantly impedes adhesion and invasion in early and late stage colorectal carcinoma cells. 2016. Molecular Medicine 22 :664-673.  doi: 10.2119/molmed.2016.00169

47. T. M. Rebelo, C. J. Chetty, .E. Ferreira, S. F. T. Weiss. Anti-LRP/LR-specific antibody IgG1-iS18 impedes adhesion and invasion of pancreatic cancer and neuroblastoma cells. 2016. BMC Cancer 16:917. DOI 10.1186/s12885-016-2953-2

48. C. Munien, T.M. Rebelo, E. Ferreira and S.F.T Weiss. IgG1-iS18 impedes the adhesive and invasive potential of early and late stage malignant melanoma cells. 2017.  Experimental Cell Research, 351, 135-141.

 49.  Otgaar, T.C., Ferreira, E., Malindisa, S., Bernert, M.,  Letsolo, B.T.  and Weiss, S.F.T. 37 kDa LRP::FLAG enhances telomerase activity and reduces senescent markers in vitro. 2017. Oncotarget, 8 (49), 86646-86656.

50.  Chetty, C. J., Ferreira, E., Jovanovic, K. and Weiss, S.F.T. Knockdown of LRP/LR induces apoptosis in pancreatic cancer and neuroblastoma cells through activation of caspases.2017. Exp Cell Research, 360, 264-272.

51.  Rebelo., T.M., Vania, L., Ferreira, E. and Weiss, S.F.T. siRNA - mediated LRP/LR knock-down reduces cellular viability of malignant melanoma cells through the activation of apoptotic caspases.

2018. Exp Cell Research, 368, 1-12.

52.  Ferreira, E.,  Bignoux, M. J., Otgaar, T.C.,  Tagliatti, N., Jovanovic, K., Letsolo, B.T. and Weiss, S.F.T. LRP/LR specific antibody IgG1-iS18 impedes neurodegeneration in Alzheimer's disease mice. 2018. Oncotarget, 9 (43) 27059-27073.

53. Vania, L., Rebelo. T.M., Ferreira, E. and Weiss, S.F.T. Knock-down of LRP/LR promotes apoptosis in early and late stage colorectal carcinoma cells via caspase activation. 2018. BMC Cancer, 18:602

54. Bignoux, M.J., Cuttler, K., Otgaar, T.O., Ferreira, E., Letsolo, B.T. and Weiss, S.F.T. 2019. LRP::FLAG rescues cells from Aβ- mediated cytotoxicity through increased TERT levels and telomerase activity. 2019. J. Alzheimer’s Disease, 69, 729-741 DOI: 10.3233/JAD-190075

55.  Cutler, K., Bignoux, M.J., Otgarr, T.C., Chigumba, S., Ferreira, E. and Weiss, S.F.T.  LRP::FLAG reduces phosphorylated tau levels in Alzheimer's Disease cell culture models. 2020.  J Alzheimer's Disease, 76, 753-768 DOI: 10.3233/JAD-200244

56.   Vania, L., Morris, G., Ferreira, E and Weiss, SFT.  Knock-down of LRP/LR influences signalling pathways in late-stage colorectal carcinoma cells.  2021, BMC Cancer.  21:392.