SA HIV-1 protease: Biochemistry, biophysics, structural biology and attractive drug target

Professor Yasien Sayed from the School of Molecular Cell Biology will present his inaugural lecture.

HIV-1 subtype C is responsible for the majority of HIV infections in southern Africa, the epicentre of the global HIV pandemic. The HIV-1 protease is an attractive drug target because it is among the three viral enzymes involved in viral replication and maturation. The development of drug resistance, however, remains one of the most significant challenges in the fight for sustained viral suppression within HIV-1-infected patients on antiretroviral therapy. In order to understand drug resistance and to enhance the efficacy of future drug molecules, an in depth study of the biochemistry, biophysics and structural biology of the viral protease and its related drugs is required.

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