Integrative Cancer Biology Research Laboratory
Our research is focused on characterising the role of cholesterol-related pathways in breast cancer. Cholesterol is an essential component of cell membrane and several types of cancer cells accumulate cholesterol to support their rapid cell division and proliferation. We have an integrated research platform where we apply knowledge gained from laboratory work (both in vitro and in vivo) and bioinformatics (analysis of lab data as well as publicly available data) to identify the molecular and signalling pathways underlying cancer cell proliferation and metastasis. A key focus of our work is to target cholesterol in the cancer cell or tumour to not only develop new therapeutic options but also to combat drug resistance in cancer. We have recently introduced the study of cholesterol in EMT and cancer stem cells to further elucidate the role that cholesterol plays in breast cancer.