MRC/Wits Rural Public Health and Health Transitions Unit (Agincourt)

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About Us

Established in 1992, the SA Medical Research Council/Wits Rural Public Health and Health Transitions Unit (Agincourt) is a globally recognised health, population and development research initiative based in rural South Africa. 

The unit is one of Africa's longest-running health and demographic surveillance systems.

Agincourt's research areas address four fundamental questions: 
  • How can we better understand and anticipate rapid, unpredictable shifts in health, population, and social transitions?
  • What are the complex interactions between social, environmental, behavioural, and biological factors that shape vulnerability and resilience across the life course?
  • When, where, and how can we intervene most effectively to drive meaningful change?
  • What are the implications for health, social, and developmental policies to create a more equitable, socially cohesive, and economically productive society?

Our primary research base sits in a fast-changing rural region, 500km northeast of Johannesburg, near Kruger National Park and southern Mozambique. 

Pioneering data infrastructure and tools

  • Making well-characterised data available to research and policy communities is a priority.
  • The Agincourt Health and Socio-Demographic Surveillance System (HDSS) holds high-resolution longitudinal data that drives new discoveries and cutting-edge research. Spanning genomic, physiological, and clinical data, it supports groundbreaking studies, cohorts, and trials across the life course.
  • Once limited to high-income settings, advanced technologies now shape our work—smartphone apps tackle adolescent depression, DXA scans assess osteoporosis, and MRI scans unlock insights into dementia.
  • We are a founding node of SAPRIN, a national research network uniting public and academic institutions to drive high-impact science. Generating critical data supports evidence-based policy and shapes a more resilient, responsive research ecosystem for the country.
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