Inaugural Lecture of Professor Mandeep Kaur
| When: | Thursday, 27 October 2022 - Thursday, 27 October 2022 |
| Where: | Hybrid Event Senate Room, 2nd Floor, Solomon Mahlangu House, Braamfontein Campus East |
| Start time: | 17:00 |
| Enquiries: | Kelebogile Tadi: Kelebogile.Tadi@wits.ac.za |
| RSVP: | Online platform: Zoom Registration link For in-person attendance RSVP: Kelebogile.Tadi@wits.ac.za |
Curbing Cancer's Craving for Cholesterol: Opportunities And Challenges.
A cell, the unit of life, has certain biological checks and balances in place that allow human body to work optimally by eradicating diseased or old cells.
On the other hand, a cancer cell develops the capability to manipulate certain internal cellular processes to its advantage, which allows it to survive and divide uncontrollably. One such process involves the synthesis, utilisation, and removal of cholesterol from cellular environment.
Normal cells have an intricate balance of cholesterol homeostasis, which is disrupted in certain types of cancer cells, thus diminishing their response to chemotherapies and ensuring their survival. Cholesterol-lowering agents may offer a new therapeutic approach to combat cancer, but this relatively new approach has its own challenges that need to be surmounted.
My laboratory is involved in identifying new therapeutic agents in this domain and to decipher the involved biological mechanisms. This lecture will discuss the role of cholesterol in cancer while addressing the potential therapeutic approaches, opportunities, and associated challenges.
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