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AMR Paed Onc

Children undergoing cancer treatment, including chemotherapy, surgery, and bone marrow transplantation, experience improved survival but face increased vulnerability to infection. Notably, bloodstream infections caused by carbapenem-resistant Enterobacterales (CRE) pose a significant threat to patients with haematological malignancies. This risk is exacerbated by increasing antimicrobial resistance.

In Africa, there is limited literature on CRE prevalence and their antimicrobial resistance patterns in paediatric oncology patients. Antimicrobial guidelines are often based on studies conducted in high income countries (HIC), necessitating tailored strategies to manage infections and protect our vulnerable patients. Further research is essential for advancing care in this context.

This project aims at assessing the prevalence, antimicrobial resistance (AMR) patterns and outcomes of Carbapenem-resistant Enterobacterales (CRE) blood stream infections (BSI) in paediatric oncology patients. It focuses on a 7-year case study experience in a Paediatric Oncology Unit at a public hospital in South Africa.

AMR Paed Onc team

Project team:

  • Dr Gugulethu Mapurisa
  • Prof Gita Naidu
  • Prof David Moore
  • Dr Prenika Jaglal
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