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The effect of perindopril, a new angiotensin converting enzyme inhibitor on the hormonal response to brisk exercise in healthy subjects

The effect of perindopril, a new angiotensin converting enzyme inhibitor on the hormonal response to brisk exercise in healthy subjects Klug, Eric, Quinton Cardiovascular drugs have varying effects on haemodynamic, metabolic, and hormonal responses to exercise. Angiotensin converting enzyme inhibitors (ACEI) have been used for the treatment of systemic hypertension, left ventricular dysfunction with or without congestive heart failure, and increasingly, for occlusive coronary artery disease and its complications.. A dissertation submitted to the Faculty of Medicine, University of the Witwatersrand, Johannesburg, for the Degree of Master of Medicine. Johannesburg 1994.

Quantification of sampling uncertainties at grade control decision points for a platinum mine

Quantification of sampling uncertainties at grade control decision points for a platinum mine Woollam, Mandi The mining industry has been challenged with rising costs and lower ore grades mined, thereby squeezing profit margins. Furthermore, with decreasing ore grades being mined, the PGE grade of interest is edging closer to the capabilities of the available analytical techniques. This is placing more pressure on maximizing the precision and accuracy of data and the importance of the quality of sampling has therefore become elevated. The quality of sampling is affected by all contributing effects that make up the sampling chain. Grade control sampling assay data is used routinely in conjunction with the geology of the ore to assign a destination for the ore (either to a stockpile or to the mill), based on its grade classification for the platinum mine. The classification of the grade for a particular mining block is made using four key elements (4E). This grade determination is often found to be different to that generated from the exploration sampling process. These differences between assay data obtained using different sampling techniques are due to errors in sampling. These errors were investigated in depth in this study. In order to understand the possible errors in the assignment of grade to a mining block, the errors at the classification thresholds (referred to as grade control decision points (GCDP)) have been investigated. These errors, comprised of both random and systematic errors and were determined independently in this study. Components that generate these errors include the heterogeneity of the ore, the action of taking a sample, sample preparation and the analytical technique used to analyse the sample. The random error associated with the assignment of grade to a particular mining block is highly dependent on the analytical technique, grade of the ore, as well as the number of assays used. The application of the central limit theorem in calculating the average grade of a block (with n=30 samples analysed in duplicate) reduces the random error by a factor of 7.75. Although this factor reduces the random error sufficiently (< 10 % at all grades) to enhance confidence, the large errors (>> 10 %) assigned to each of the individual thirty samples (at grades less than 1.7 g/t 4E) still present a risk of incorrect classification of the ore below 1.7 g/t 4E. The effect of systematic errors are additive and cannot be reduced by averaging more assays (unlike random error). These errors have their origin in the “design” of the sampling protocol. This study highlighted that, in general, the grade calculated for a mine area will be lower when calculated using grade control assay data when compared with the grade calculated if exploration assay data were used. This systematic error was also found to change in magnitude and sign depending on the 4E grade of the ore. The grade at which mining is viable (pay-limit of the mine) is defined in the 2015 annual report as 2.5 g/t 4E. This study, quantified the smallest systematic error (< ± 2 %) between the two sampling techniques at ore grades equal to 1.7 g/t 4E. Both these grades (2.5 and 1.7 g/t) are significant in that it is the upper and lower grade limit for the very low grade ore (VLGO) category. Ore that is assigned to grade categories higher than 2.5 g/t 4E, will be marked as destined for the milling process in mining. It is at this grade that the error should be minimised so as to minimise financial loss; such loss will occur when ore is stockpiled but should have been processed or when ore is diluted with sub-standard grades, which should have rather been stockpiled. This study quantified the errors associated with grade control into all its contributing parts; the largest error (- 8 %) was assigned to the sample preparation component of the sampling protocol. All other components were quantified as an average error and this was done at the mine’s different ore grades. Sampling design (quality assurance) components that present an opportunity to reduce the systematic errors were identified as: • Increased sub-sampling, sample mass • Re-design, sub-sampling sample cups • Protect the integrity of the analytical sample; through the introduction of a third sample cup to obtain the sample required for geological logging • Optimize the drilling speed of the reverse circulation drill • Optimize the rotational speed of the rota-port cone splitter • Centre the cone splitter perfectly below the falling sample stream • Increase the analytical sample mass (to a maximum) • Modification of sample preparation (eliminating the crushing stage) • Minimise loss of fines during sampling and sample preparation Additional quality control (QC) activities were recommended; these will reveal “out of (statistical) control”, sampling components. The cost of incorrect classification of ore is difficult to quantify but when mining tonnages are considered, it is certain to be significant. Using the average realised basket price ZAR / Pt (oz) for 2016, the value of ore (at 2.5 g/t 4E) from a three hundred tonne truck, is calculated to be around R287,666. Thus if a truck is incorrectly assigned to stockpile instead of processing this value will be lost. Resources invested in the resolution of these systematic errors will be resources well spent. Management should be commended for investing in heterogeneity and twin-hole test work, both of which provide information that quantify and identify sampling errors. Measuring these errors is the first step towards reduction or elimination of error. A Project Report submitted to the Faculty of Engineering and the Built Environment, University of Witwatersrand, Johannesburg, in partial fulfillment of the requirements for the degree of Masters in Science in Engineering .

Endothelial dysfunction in familial hypercholesterolaemia

Endothelial dysfunction in familial hypercholesterolaemia Brown, Susan, Lynn Untreated patients with heterozygous familial hypercholesterolaemia (hFH) are at increased risk for atherosclerosis. Surrogate markers to predict atheroma include the presence of endothelial dysfunction (ED) as well as increased levels of inflammatory markers A research report submitted to the Faculty of Health Sciences, University of the Witwatersrand in fulfilment of the requirements for the Degree of Master of Medicine in the branch of Internal Medicine

Possible effects of hormonal contraceptives on human and baboon mitosis chromosomes

Possible effects of hormonal contraceptives on human and baboon mitosis chromosomes Pinto, Maximina, Rodrigues Hormonal - contraceptives - ' the pill ' as it is known to the general public - are among the most universally used drugs in our contemporary world. Daily millions of health young women are taking the ' pill ' for a purpose other than the control of disease A Thesis submitted to the Faculty of Medicine University of the Witwatersrand,, Johannesburg, for a Degree of Doctor of Philosophy