Qualifications: BSc, BSc (Hons), PhD (Rhodes University)
Phone: 011 717 6744
Room: 403 Humphrey Raikes Building
My current research interest is mainly in the area of HIV: design and synthesis of novel protease inhibitors and nucleoside and non-nucleoside reverse transcriptase inhibitors (NRTIs and NNRTIs); and use of enzymes in organic synthesis (biocatalysis), with a particular interest in the cost-effective preparation of generic antiretrovirals. Recent research has been concerned with the preparation of HIV protease inhibitors using a multi-component coupling reaction approach (Passerini), as well as preparation of imidazo[1,2-a]pyridines and related compounds as HIV NNRTIs.
M.L. Bode, S.R. Buddoo, S.H. Minnaar and C.A. du Plessis. Extraction, isolation and NMR data of the tetraether lipid calditoglycerocaldarchaeol (GDNT) from Sulfolobus metallicus harvested from a bioleaching reactor. Chemistry and Physics of Lipids, 2008, 154, 94.
H.H. Kinfe, V. Chhiba, J. Frederick, M.L. Bode, K. Mathiba, P.A. Steenkamp, D. Brady. Enantioselective hydrolysis of β-hydroxy nitriles using the whole cell biocatalyst of Rhodococcus rhodochrous ATCC BAA-870. Journal of Molecular Catalysis B: Enzymatic, 2009, 59, 231.
M.L. Bode, P.J. Gates, S.Y. Gebretnsae, R. Vleggaar. Structure elucidation and stereoselective total synthesis of pavettamine, the causal agent of gousiekte. Tetrahedron, 2010, 66, 2026.
D.F. Visser, K.J. Rashamuse, F. Hennessy, G.E.R. Gordon, P.J. van Zyl, K. Mathiba, M.L. Bode and D. Brady. High-yielding cascade enzymatic synthesis of 5-methyluridine using a novel combination of nucleoside phosphorylases. Biocatalysis and Biotransformation, 2010, 28, 245.
G.E.R. Gordon, D.F. Visser, D. Brady, N. Raseroka and M.L. Bode. Defining a process operating window for the synthesis of 5-methyluridine by transglycosylation of guanosine and thymine. Journal of Biotechnology, 2011, 151, 108.
G.E.R. Gordon, M.L. Bode, D.F. Visser, M.J. Lepuru, J.G. Zeevaart, N. Ragubeer, M. Ratsaka, D.R. Walwyn and D. Brady. An integrated chemo-enzymatic route for preparation of β-thymidine, a key intermediate in the preparation of antiretrovirals. Organic Process Research and Development, 2011, 15, 258.
M.L. Bode, D. Gravestock, S.S. Moleele, C.W. van der Westhuyzen, S.C. Pelly, P.A. Steenkamp, H.C. Hoppe, T. Khan and L.A. Nkabinde. Imidazo[1,2-a]pyridin-3-amines as potential HIV-1 non-nucleoside reverse transcriptase inhibitors. Bioorganic and Medicinal Chemistry, 2011, 19, 4227.
V. Chhiba, M.L. Bode, K. Mathiba, W. Kwezi, D. Brady. Enantioselective biocatalytic hydrolysis of β-aminonitriles to β-amino-amides using Rhodococcus rhodochrous ATCC BAA-870. Journal of Molecular Catalysis B: Enzymatic, 2012, 76, 68.
D.F. Visser, G.E.R. Gordon, M.L Bode, K. Mathiba and D. Brady. (2012). Enzymatic synthesis of 5-methyluridine by transglycosylation of guanosine and thymine. Practical Methods for Biocatalysis and Biotransformations Vol 2. John Whittall, Peter Sutton (Eds), pp. 243-248. ISBN: 978-1-1199-9139-7.
D. Gravestock, A.L. Rousseau, A.C.U. Lourens, H.C. Hoppe, L.A. Nkabinde and M.L. Bode. Novel branched isocyanides as useful building blocks in the Passerini-amine deprotection-acyl migration (PADAM) synthesis of potential HIV-1 protease inhibitors. Tetrahedron Letters, 2012, 53, 3225.